Pediatric Population Reference Value Distributions for Cancer Biomarkers: A CALIPER Study of Healthy Community Children
نویسندگان
چکیده
As part of CALIPER program, a national research initiative aimed at closing the gaps in pediatric reference intervals, I sought to develop a database of covariate-stratified reference intervals in children for 11 circulating tumor markers in accordance with CLSI C28-A3 guidelines. Healthy children from birth to 18 years were recruited to participate in CALIPER and serum samples from 400-700 subjects were analyzed on the Abbott Architect ci4100TM. Significant fluctuations in biomarker concentrations by age and/or gender were observed in 10 of 11 biomarkers. Age partitioning was required for CA 15-3, CA 125, CA 19-9, CEA, SCC, ProGRP, Total & Free PSA, HE4 and AFP, and gender partitioning was required for CA 125, CA 19-9, Total & Free PSA. The establishment of these reference intervals will aid in harnessing the full potential of tumor markers in a pediatric population and in research aimed at determining the clinical value
منابع مشابه
Pediatric population reference value distributions for cancer biomarkers and covariate-stratified reference intervals in the CALIPER cohort.
BACKGROUND Cancer biomarkers are commonly used in pediatrics to monitor cancer progression, recurrence, and prognosis, but pediatric reference value distributions have not been well established for these markers. The Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER) sought to develop a pediatric database of covariate-stratified reference value distributions for 11 key ci...
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Clinical laboratory reference intervals provide valuable information to medical practitioners in their interpretation of quantitative laboratory test results, and therefore are critical in the assessment of patient health and in clinical decision-making. The reference interval serves as a health-associated benchmark with which to compare an individual test result. Unfortunately, critical gaps c...
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1. Rovnaghi CR, Kala AF, Allen SL, Anand KS. Interpretation of cortisol concentrations and reference intervals from the CALIPER database [Letter]. Clin Chem 2014;60:418–9. 2. Bailey D, Colantonio D, Kyriakopoulou L, Cohen AH, Chan MK, Armbruster D, Adeli K. Marked biological variance in endocrine and biochemical markers in childhood: establishment of pediatric reference intervals using healthy ...
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BACKGROUND Reference intervals are indispensable in evaluating laboratory test results; however, appropriately partitioned pediatric reference values are not readily available. The Canadian Laboratory Initiative for Pediatric Reference Intervals (CALIPER) program is aimed at establishing the influence of age, sex, ethnicity, and body mass index on biochemical markers and developing a comprehens...
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